• Combination of berberine extracts from natural plant sources
• Traditionally used in Herbal Medicine as a bitter to aid digestion, to help relieve digestive disturbances such as dyspepsia, and as a mild laxative
• Includes goldenseal root extract, barberry root extract, barberry root bark, Oregon grape root extract, and Oregon grape root
• Berberis Formula is a blend of barberry, goldenseal and Oregon grape extracts that are traditionally used in Herbal Medicine to help maintain gastrointestinal health. The main bioactive ingredient in these extracts is berberine.1,2 Recent research demonstrates that berberine inhibits bacterial attachment to the gastric mucosa.3

Berberine also mediates the transport of ions and water across intestinal epithelial cells.3

It helps maintain the balance between electrolytes and water, resulting in an anti-diarrheal effect.3

Berberine can increase the expression of the Na+;H+ exchanger and aquaporin 2, which help enhance the absorption of sodium and water, respectively.3,4 Berberine also promotes proper intestinal epithelial tight junction formation, and decreases the permeability of these cells to promote appropriate gastrointestinal barrier function.5 During low contractile states, berberine stimulates the jejunum through the activation of muscarinic receptors, resulting in increased intestinal motility, and a mild laxative effect.6

NPN 80034907
07519180

1. Javadzadeh, SM, Ebrahimi, A. The traditional uses and pharmacological effects of different parts Berberis Vulgaris. Sci. Agri. 2013; 1(2): 61-66.
2. Siow, YL, Sarna, L, O, K. Redox regulation in health and disease - Therapeutic potential of berberine. Food Research International. 2011; 44: 2409-2417.
3. Chen, C, Yu, Z, Li, Y, Fichna, J, Storr, M. Effects of Berberine in the Gastrointestinal Tract - A Review of Actions and Therapeutic Implications. The American Journal of Chinese Medicine. 2014; 42(5): 1053-1070.
4. Zhang, Y, Wang, X, Sha, S, Liang, S, Zhao, L, Liu, L, Chai, N, Wang, H, Wu, K. Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model. Fitoterapia. 2012; 83: 1014-1022.
5. Gu, L, Li, N, Gong, J, Li, Q, Zhu, W, Li, J. Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia. The Journal of Infectious Diseases. 2011; 203: 1602-1612.
6. Chen, DP, Xiong, YJ, Lv, BC, Liu, FF, Wang, L, Tang, ZY, Lin, Y. Effects of berberine on rat jejunal motility. Journal of Pharmacy and Pharmacology. 2013; 65(5): 734-744.