Lipoic acid increases the need for biotin by lowering levels of biotin-dependent enzymes. Thus Lipoic Acid should always be taken with biotin. Lipoic Acid has been extensively researched for its applications in blood sugar metabolism, heavy metal detoxification, liver health and hepatitis. Lipoic acid has also been studied for its effects on the aging process and in the prevention of wrinkling by protecting collagen in the skin.